Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2′ Moiety

por Hu, Zilun, Wong, Pancras C., Gilligan, Paul J., Han, Wei, Pabbisetty, Kumar B., Bozarth, Jeffrey M., Crain, Earl J., Harper, Timothy, Luettgen, Joseph M., Myers, Joseph E., Ramamurthy, Vidhyashankar, Rossi, Karen A., Sheriff, Steven, Watson, Carol A., Wei, Anzi, Zheng, Joanna J., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Publicado en ACS Med Chem Lett (2015)