Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2′ Moiety

af Hu, Zilun, Wong, Pancras C., Gilligan, Paul J., Han, Wei, Pabbisetty, Kumar B., Bozarth, Jeffrey M., Crain, Earl J., Harper, Timothy, Luettgen, Joseph M., Myers, Joseph E., Ramamurthy, Vidhyashankar, Rossi, Karen A., Sheriff, Steven, Watson, Carol A., Wei, Anzi, Zheng, Joanna J., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Udgivet i ACS Med Chem Lett (2015)