Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice

Por Behm, David J, Harrison, Stephen M, Ao, Zhaohui, Maniscalco, Kristeen, Pickering, Susan J, Grau, Evelyn V, Woods, Tina N, Coatney, Robert W, Doe, Christopher P A, Willette, Robert N, Johns, Douglas G, Douglas, Stephen A
Publicado em 2003

The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and...

Por Behm, David J, Stankus, Gerald, Doe, Christopher P A, Willette, Robert N, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Nuthulaganti, Parvathi, Fornwald, James A, Ames, Robert S, Lambert, David G, Calo', Girolamo, Camarda, Valeria, Aiyar, Nambi V, Douglas, Stephen A
Publicado em 2006

Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

Por Jia, Lanqi, Simpson, Robert D., Yuan, Jing, Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Tice, Colin M., Guo, Joan, Ishchenko, Alexey, Singh, Suresh B., Wu, Zhongren, McKeever, Brian M., Bukhtiyarov, Yuri, Johnson, Judith A., Doe, Christopher P., Harrison, Richard K., McGeehan, Gerard M., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.
Publicado em 2011