Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

od Rice, Kenneth D., Aay, Naing, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Bussenius, Joerg, Costanzo, Simona, Curtis, Jeffry K., Defina, Steven C., Dubenko, Larisa, Engst, Stefan, Joshi, Anagha A., Kennedy, Abigail R., Kim, Angie I., Koltun, Elena S., Lougheed, Julie C., Manalo, Jean-Claire L., Martini, Jean-Francois, Nuss, John M., Peto, Csaba J., Tsang, Tsze H., Yu, Peiwen, Johnston, Stuart
Izdano 2012