Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

Por Just, Stefan, Chenard, Bertrand L., Ceci, Angelo, Strassmaier, Timothy, Chong, Jayhong A., Blair, Nathaniel T., Gallaschun, Randall J., del Camino, Donato, Cantin, Susan, D’Amours, Marc, Eickmeier, Christian, Fanger, Christopher M., Hecker, Carsten, Hessler, David P., Hengerer, Bastian, Kroker, Katja S., Malekiani, Sam, Mihalek, Robert, McLaughlin, Joseph, Rast, Georg, Witek, JoAnn, Sauer, Achim, Pryce, Christopher R., Moran, Magdalene M.
Publicado no PLoS One (2018)

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Por Lin, Brian Leei, Matera, Damian, Doerner, Julia F., Zheng, Nan, del Camino, Donato, Mishra, Sumita, Bian, Hong, Zeveleva, Svetlana, Zhen, Xiaoguang, Blair, Nathaniel T., Chong, Jayhong A., Hessler, David P., Bedja, Djahida, Zhu, Guangshuo, Muller, Grace K., Ranek, Mark J., Pantages, Lynn, McFarland, Mary, Netherton, Matthew R., Berry, Angela, Wong, Diane, Rast, Georg, Qian, Hu Sheng, Weldon, Steven M., Kuo, Jay J., Sauer, Achim, Sarko, Chris, Moran, Magdalene M., Kass, David A., Pullen, Steven S.
Publicado no Proc Natl Acad Sci U S A (2019)