Resultados da pesquisa - safety after forced phase 1

Pesquisas alternativas:
after forced » after focal (Expandir a Pesquisa), after failed (Expandir a Pesquisa), after food (Expandir a Pesquisa)
forced phase » force phase (Expandir a Pesquisa), formed phase (Expandir a Pesquisa), sourced phase (Expandir a Pesquisa)
phase 1 » phase _ (Expandir a Pesquisa), phase 2 (Expandir a Pesquisa)

1

Safety and Dose Study of Targeted Lung Denervation in Moderate/Severe COPD Patients

Safety and Dose Study of Targeted Lung Denervation in Moderate/Severe COPD Patients

Por Valipour, Arschang, Shah, Pallav L., Pison, Christophe, Ninane, Vincent, Janssens, Wim, Perez, Thierry, Kessler, Romain, Deslee, Gaetan, Garner, Justin, Abele, Christine, Hartman, Jorine E., Slebos, Dirk-Jan
Publicado no Respiration (2019)

“... confirmation phase study to confirm safety improvements after procedural enhancements following...”
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2

Phase I/II Study of Inhaled Doxorubicin Combined with Platinum-Based Therapy for Advanced Non–Small Cell Lung Cancer

Phase I/II Study of Inhaled Doxorubicin Combined with Platinum-Based Therapy for Advanced Non–Small Cell Lung Cancer

Por Otterson, Gregory A., Villalona-Calero, Miguel A., Hicks, William, Pan, Xueliang, Ellerton, John A., Gettinger, Scott N., Murren, John R.
Publicado no Clin Cancer Res (2010)

“... expiratory volume in 1 second/forced vital capacity ≥50%, resting/exercise O(2) saturation ≥90%/85%. In phase...”
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3

Phase I Trial of Repeated Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis

Phase I Trial of Repeated Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis

Por Oh, Ki-Wook, Moon, Chanil, Kim, Hyun Young, Oh, Sung-il, Park, Jinseok, Lee, Jun Ho, Chang, In Young, Kim, Kyung Suk, Kim, Seung Hyun
Publicado no Stem Cells Transl Med (2015)

“... of autologous bone marrow mesenchymal stromal cells in ALS. After the clinical trial (phase I/II) was conducted...”
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4

Phase II Study of Chemoembolization With Drug-Eluting Beads in Patients With Hepatic Neuroendocrine Metastases: High Incidence of Biliary Injury

Phase II Study of Chemoembolization With Drug-Eluting Beads in Patients With Hepatic Neuroendocrine Metastases: High Incidence of Biliary Injury

Por Bhagat, Nikhil, Reyes, Diane K., Lin, Mingde, Kamel, Ihab, Pawlik, Timothy M., Frangakis, Constantine, Geschwind, J. F.
Publicado em 2012

“... were allowed. Tumor response was assessed by magnetic resonance imaging 1 month after treatment using...”
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5

A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma

A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma

Por Roskos Lorin, Faggioni Raffaella, Molfino Nestor A, Kane Binita, Singh Dave, Woodcock Ashley
Publicado em 2010-01-01

“... multiple-dose, randomised, double-blind, placebo-controlled phase 1 study in asthmatics (forced expiratory...”
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6

A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma

A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma

Por Singh, Dave, Kane, Binita, Molfino, Nestor A, Faggioni, Raffaella, Roskos, Lorin, Woodcock, Ashley
Publicado em 2010

“..., placebo-controlled phase 1 study in asthmatics (forced expiratory volume in 1 second [FEV(1)] ≥ 80...”
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7

Inhalation of a Dry Powder Ciprofloxacin Formulation in Healthy Subjects: A Phase I Study

Inhalation of a Dry Powder Ciprofloxacin Formulation in Healthy Subjects: A Phase I Study

Por Stass, Heino, Nagelschmitz, Johannes, Willmann, Stefan, Delesen, Heinz, Gupta, Abhishek, Baumann, Sybille
Publicado em 2013

“... ciprofloxacin DPI administration. METHODS: This was a phase I, single-dose, single-site, randomized, single...”
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8

Improvements in Lung Function with Nebulized Revefenacin in the Treatment of Patients with Moderate to Very Severe COPD: Results from Two Replicate Phase III Clinical Trials

Improvements in Lung Function with Nebulized Revefenacin in the Treatment of Patients with Moderate to Very Severe COPD: Results from Two Replicate Phase III Clinical Trials

Por Ferguson, Gary T., Feldman, Gregory, Pudi, Krishna K., Barnes, Chris N., Moran, Edmund J., Haumann, Brett, Pendyala, Srikanth, Crater, Glenn
Publicado no Chronic Obstr Pulm Dis (2019)

“... FEV(1 )and peak FEV(1) (0-2 hours after first dose). Safety assessments included treatment-emergent...”
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9

Lebrikizumab in the personalized management of asthma

Lebrikizumab in the personalized management of asthma

Por Thomson, Neil C, Patel, Manish, Smith, Andrew D
Publicado em 2012

“... and safety of lebrikizumab in humans, and progress in patient selection for lebrikizumab therapy. IL-13 is a...”
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10

Efficacy and Safety of Roflumilast in Korean Patients with COPD

Efficacy and Safety of Roflumilast in Korean Patients with COPD

Por Lee, Jae Seung, Hong, Yoon Ki, Park, Tae Sun, Lee, Sei Won, Oh, Yeon-Mok, Lee, Sang-Do
Publicado no Yonsei Med J (2016)

“... obstructive pulmonary disease (COPD) patients [post-bronchodilator forced expiratory volume in 1 second (FEV(1...”
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11

Clinical outcomes in idursulfase-treated patients with mucopolysaccharidosis type II: 3-year data from the hunter outcome survey (HOS)

Clinical outcomes in idursulfase-treated patients with mucopolysaccharidosis type II: 3-year data from the hunter outcome survey (HOS)

Por Muenzer, Joseph, Giugliani, Roberto, Scarpa, Maurizio, Tylki-Szymańska, Anna, Jego, Virginie, Beck, Michael
Publicado no Orphanet J Rare Dis (2017)

“..., individuals who had received a bone marrow transplant and those enrolled in the phase 1/2 [TKT018] or phase 2...”
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12

Phase I, Dose-Escalating Study of the Safety and Pharmacokinetics of Inhaled Dry-Powder Vancomycin (AeroVanc) in Volunteers and Patients with Cystic Fibrosis: a New Approach to Therapy for Methicillin-Resistant Staphylococcus aureus

Phase I, Dose-Escalating Study of the Safety and Pharmacokinetics of Inhaled Dry-Powder Vancomycin...

Por Waterer, Grant, Lord, John, Hofmann, Thomas, Jouhikainen, Taneli
Publicado no Antimicrob Agents Chemother (2020)

“... for inhalation (AeroVanc). Here, we report a phase I, single-dose, dose-escalating study aimed at demonstrating...”
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13

Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease

Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease

Por Bai, Chunxue, Ichinose, Masakazu, Lee, Sang Haak, Lee, Kwan Ho, Jöns, Olaf, Bothner, Ulrich, Zhao, Yihua, Buhl, Roland
Publicado no Int J Chron Obstruct Pulmon Dis (2017)

“..., tiotropium, or olodaterol. We assessed the forced expiratory volume in 1 second (FEV(1)) area under the curve...”
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14

Imidafenacin, An Orally Active Muscarinic Receptor Antagonist, Improves Pulmonary Function In Patients With Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled 3×3 Crossover Phase II Trial

Imidafenacin, An Orally Active Muscarinic Receptor Antagonist, Improves Pulmonary Function In Patients With Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled 3×3 Crossover Phase II Trial

Por Machida, Kentaro, Kawayama, Tomotaka, Kinoshita, Masaharu, Ichinose, Masakazu, Tsuda, Tohru, Takata, Shohei, Koto, Hiroshi, Yoshida, Makoto, Ashihara, Yoshinori, Kawashima, Masaru, Suna, Hideaki, Inoue, Hiromasa
Publicado no Int J Chron Obstruct Pulmon Dis (2019)

“... crossover Phase II trial was performed to evaluate the efficacy and safety of oral administration...”
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15

Randomized phase 2 trial of NP001–a novel immune regulator: Safety and early efficacy in ALS

Randomized phase 2 trial of NP001–a novel immune regulator: Safety and early efficacy in ALS

Por Miller, Robert G., Block, Gilbert, Katz, Jonathan S., Barohn, Richard J., Gopalakrishnan, Vidhya, Cudkowicz, Merit, Zhang, Jane R., McGrath, Michael S., Ludington, Elizabeth, Appel, Stan H., Azhir, Ari
Publicado no Neurol Neuroimmunol Neuroinflamm (2015)

“..., NP001 1 mg/kg, or placebo for 6 months. Safety, tolerability, and inflammatory biomarkers were...”
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16

A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma

A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose...

Por Swystun, Veronica, Green, Francis H. Y., Dennis, John H., Rampakakis, Emmanouil, Lalli, Gurkeet, Fadayomi, Morenike, Chiu, Andrea, Shrestha, Grishma, El Shahat, Sharif Galal, Nelson, David Evan, El Mays, Tamer Y., Pieron, Cora A., Leigh, Richard
Publicado no Trials (2018)

“... response (measured as the forced expiratory volume in 1 s or FEV(1)) over time, the area under the curve...”
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17

Efficacy and safety of nintedanib in advanced idiopathic pulmonary fibrosis

Efficacy and safety of nintedanib in advanced idiopathic pulmonary fibrosis

Por Yoon, Hee-Young, Park, Sojung, Kim, Dong Soon, Song, Jin Woo
Publicado no Respir Res (2018)

“...BACKGROUND: Phase 3 trials have shown that nintedanib reduces the decline in forced vital capacity...”
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18

Efficacy, safety, and tolerability of once‐daily abediterol in patients with stable, persistent asthma: a Phase II, randomized, 7‐day, crossover study

Efficacy, safety, and tolerability of once‐daily abediterol in patients with stable, persistent asthma: a Phase II, randomized, 7‐day, crossover study

Por Beier, Jutta, Fuhr, Rainard, Seoane, Beatriz, Massana, Eric, de Miquel, Gonzalo, Pujol, Helena, Ruiz, Sandrine
Publicado no Pharmacol Res Perspect (2017)

“... to one of four treatment sequences (1:1:1:1). Follow‐up was 7 days after final treatment. Spirometry...”
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19

An Open-Label, Phase II Study of the Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (PIPF-002)

An Open-Label, Phase II Study of the Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (PIPF-002)

Por Gotfried, Mark H., Girod, Carlos E., Antin-Ozerkis, Danielle, Burgess, Tracy, Strombom, Indiana, Stauffer, John L., Kirchgaessler, Klaus-Uwe, Padilla, Maria L.
Publicado no Pulm Ther (2018)

“...INTRODUCTION: PIPF-002 was a phase 2, multicenter, open-label study of pirfenidone in patients...”
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20

Efficacy and Safety of Aclidinium Bromide Compared with Placebo and Tiotropium in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease: Results from a 6-week, Randomized, Controlled Phase Iiib Study

Efficacy and Safety of Aclidinium Bromide Compared with Placebo and Tiotropium in Patients...

Por Beier, Jutta, Kirsten, Anne-Marie, Mróz, Robert, Segarra, Rosa, Chuecos, Ferran, Caracta, Cynthia, Gil, Esther Garcia
Publicado em 2013

“... from baseline in forced expiratory volume in 1 second area under the curve for the 24-hour period post...”
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