“... that the pacemaking “engine” from I(NaP) is an inherent property of CA1 pyramidal neurons that can be engaged...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“... one inward current is activated. This current is almost completely insensitive to TTX but can...”
Obter o texto integral
Obter o texto integral

“... there is a voltage- and time-dependent K+ current (iKdd) that can be separated from the hyperpolarization...”
Obter o texto integral
Obter o texto integral

“...). Thus, in response to (i) a train of voltage-clamp pulses or (ii) a series of action potentials...”
Obter o texto integral
Obter o texto integral

“... clamp depolarizations the net outward current first increases to a maximum at 150 msec and then declines...”
Obter o texto integral
Obter o texto integral

“... with near-anoxic oxygen tension. Here, using oxygen clamp in on-chip picochambers, we exposed single resting...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“.... In conclusion, both I(CaL) inactivation and I(NCX) activation, using a subcomponent analysis, can be used...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“... nonmonotonic shape, reaching a minimum (generally <1 pA) between −60 and −55 mV. Under voltage clamp, ramps...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“... of such interneuronal networks will be either synchrony (near zero phase lag) or antisynchrony (phase lag near one-half...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“...1. We studied the immediate and short-term effects of UV light in the near-visible range...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“...(in) and τ(m) relies on the fast activation of I(NaP). Using dynamic clamp in hippocampal CA1 pyramidal...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“..., tetanic stimulation near the cell layers elicited a delayed depolarization (slow EPSP; duration up to 60...”
Obter o texto integral
Obter o texto integral

“... Purkinje myocytes using the single microelectrode voltage-clamp technique. We found a sigmoidal voltage...”
Obter o texto integral
Obter o texto integral

“... GxTX-1E produced near-saturating block of a component of current typically constituting ∼60–80...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“... at near-threshold levels of agonist. Unexpectedly, depolarization also stimulated an [Ca(2+)](i) increase...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“... or slightly enhanced by doubling the external K+ concentration. Io was also characterized by a linear I-V...”
Obter o texto integral
Obter o texto integral

“... of these currents can also perturb physiological responses of a neuron that might underlie pathological states...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

“...1. Whole-cell and patch-clamp techniques (Hamill, Marty, Neher, Sakmann & Sigworth, 1981) have been...”
Obter o texto integral
Obter o texto integral

“..., and a one-microelectrode voltage clamp was used to record the slow outward K+ currents. In normal [K+]o...”
Obter o texto integral
Obter o texto integral

“... studies showed that DHPG elicits a Ca(2+)-dependent nonselective cation current (I(CAN)) in the dendrites...”
Obter o texto integral
Obter o texto integral
Obter o texto integral