Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia

Por Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O. Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J. Yang, Fieke W. Hoff, Marcin Kaminski, Katarzyna Tomczak, R. Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J. Jabbour, M. Emilia Di Francesco, David T. Teachey, Terzah M. Horton, Steven Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R. Marszalek, Philip L. Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang, Marina Konopleva
Publicado em 2022-05-01

Frequency modulation of a bacterial quorum sensing response

Por Vera Bettenworth, Simon van Vliet, Bartosz Turkowyd, Annika Bamberger, Heiko Wendt, Matthew McIntosh, Wieland Steinchen, Ulrike Endesfelder, Anke Becker
Publicado em 2022-05-01

Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers

Por N. Shukla, M. F. Levine, G. Gundem, D. Domenico, B. Spitzer, N. Bouvier, J. E. Arango-Ossa, D. Glodzik, J. S. Medina-Martínez, U. Bhanot, J. Gutiérrez-Abril, Y. Zhou, E. Fiala, E. Stockfisch, S. Li, M. I. Rodriguez-Sanchez, T. O’Donohue, C. Cobbs, M. H. A. Roehrl, J. Benhamida, F. Iglesias Cardenas, M. Ortiz, M. Kinnaman, S. Roberts, M. Ladanyi, S. Modak, S. Farouk-Sait, E. Slotkin, M. A. Karajannis, F. Dela Cruz, J. Glade Bender, A. Zehir, A. Viale, M. F. Walsh, A. L. Kung, E. Papaemmanuil
Publicado em 2022-05-01

SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

Por Wuji Zhang, Brendon Y. Chua, Kevin J. Selva, Lukasz Kedzierski, Thomas M. Ashhurst, Ebene R. Haycroft, Suzanne K. Shoffner-Beck, Luca Hensen, David F. Boyd, Fiona James, Effie Mouhtouris, Jason C. Kwong, Kyra Y. L. Chua, George Drewett, Ana Copaescu, Julie E. Dobson, Louise C. Rowntree, Jennifer R. Habel, Lilith F. Allen, Hui-Fern Koay, Jessica A. Neil, Matthew J. Gartner, Christina Y. Lee, Patiyan Andersson, Sadid F. Khan, Luke Blakeway, Jessica Wisniewski, James H. McMahon, Erica E. Vine, Anthony L. Cunningham, Jennifer Audsley, Irani Thevarajan, Torsten Seemann, Norelle L. Sherry, Fatima Amanat, Florian Krammer, Sarah L. Londrigan, Linda M. Wakim, Nicholas J. C. King, Dale I. Godfrey, Laura K. Mackay, Paul G. Thomas, Suellen Nicholson, Kelly B. Arnold, Amy W. Chung, Natasha E. Holmes, Olivia C. Smibert, Jason A. Trubiano, Claire L. Gordon, Thi H. O. Nguyen, Katherine Kedzierska
Publicado em 2022-05-01

BMP4 drives primed to naïve transition through PGC-like state

Por Shengyong Yu, Chunhua Zhou, Jiangping He, Zhaokai Yao, Xingnan Huang, Bowen Rong, Hong Zhu, Shijie Wang, Shuyan Chen, Xialian Wang, Baomei Cai, Guoqing Zhao, Yuhan Chen, Lizhan Xiao, He Liu, Yue Qin, Jing Guo, Haokaifeng Wu, Zhen Zhang, Man Zhang, Xiaoyang Zhao, Fei Lan, Yixuan Wang, Jiekai Chen, Shangtao Cao, Duanqing Pei, Jing Liu
Publicado em 2022-05-01

Visual barcodes for clonal-multiplexing of live microscopy-based assays

Por Tom Kaufman, Erez Nitzan, Nir Firestein, Miriam Bracha Ginzberg, Seshu Iyengar, Nish Patel, Rotem Ben-Hamo, Ziv Porat, Jaryd Hunter, Andreas Hilfinger, Varda Rotter, Ran Kafri, Ravid Straussman
Publicado em 2022-05-01

Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread

Por Xiaokang Zhang, Mengkui Cui, Shuoshuo Wang, Fei Han, Pingping Xu, Luyao Teng, Hang Zhao, Ping Wang, Guichu Yue, Yong Zhao, Guangfeng Liu, Ke Li, Jicong Zhang, Xiaoping Liang, Yingying Zhang, Zhiyuan Liu, Chao Zhong, Weizhi Liu
Publicado em 2022-05-01

Ranking threats to biodiversity and why it doesn’t matter

Por Céline Bellard, Clara Marino, Franck Courchamp
Publicado em 2022-05-01

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Por Cheng Yang, Qianni Wu, Junqing Liu, Jingshan Mo, Xiangling Li, Chengduan Yang, Ziqi Liu, Jingbo Yang, Lelun Jiang, Weirong Chen, Hui-jiuan Chen, Ji Wang, Xi Xie
Publicado em 2022-05-01

Free charge photogeneration in a single component high photovoltaic efficiency organic semiconductor

Por Michael B. Price, Paul A. Hume, Aleksandra Ilina, Isabella Wagner, Ronnie R. Tamming, Karen E. Thorn, Wanting Jiao, Alison Goldingay, Patrick J. Conaghan, Girish Lakhwani, Nathaniel J. L. K. Davis, Yifan Wang, Peiyao Xue, Heng Lu, Kai Chen, Xiaowei Zhan, Justin M. Hodgkiss
Publicado em 2022-05-01

Mutational landscape of normal epithelial cells in Lynch Syndrome patients

Por Bernard C. H. Lee, Philip S. Robinson, Tim H. H. Coorens, Helen H. N. Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A. Sanders, Hoi Cheong Siu, James Hewinson, Sarah S. K. Yue, Wai Yin Tsui, Annie S. Y. Chan, Anthony K. W. Chan, Siu Lun Ho, Peter J. Campbell, Inigo Martincorena, Simon J. A. Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R. Stratton
Publicado em 2022-05-01

Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits

Por Sebastian May-Wilson, Nana Matoba, Kaitlin H. Wade, Jouke-Jan Hottenga, Maria Pina Concas, Massimo Mangino, Eryk J. Grzeszkowiak, Cristina Menni, Paolo Gasparini, Nicholas J. Timpson, Maria G. Veldhuizen, Eco de Geus, James F. Wilson, Nicola Pirastu
Publicado em 2022-05-01

Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

Por Ori Hassin, Nishanth Belugali Nataraj, Michal Shreberk-Shaked, Yael Aylon, Rona Yaeger, Giulia Fontemaggi, Saptaparna Mukherjee, Martino Maddalena, Adi Avioz, Ortal Iancu, Giuseppe Mallel, Anat Gershoni, Inna Grosheva, Ester Feldmesser, Shifra Ben-Dor, Ofra Golani, Ayal Hendel, Giovanni Blandino, David Kelsen, Yosef Yarden, Moshe Oren
Publicado em 2022-05-01

The planarian wound epidermis gene equinox is required for blastema formation in regeneration

Por M. Lucila Scimone, Jennifer K. Cloutier, Chloe L. Maybrun, Peter W. Reddien
Publicado em 2022-05-01

Codon-specific Ramachandran plots show amino acid backbone conformation depends on identity of the translated codon

Por Aviv A. Rosenberg, Ailie Marx, Alex M. Bronstein
Publicado em 2022-05-01

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Por Naoki Itokawa, Motohiko Oshima, Shuhei Koide, Naoya Takayama, Wakako Kuribayashi, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Satoshi Yamazaki, Kiyoshi Yamaguchi, Yoichi Furukawa, Koji Eto, Atsushi Iwama
Publicado em 2022-05-01

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells

Por Jiawei Zhang, Yichao Gan, Hongzhi Li, Jie Yin, Xin He, Liming Lin, Senlin Xu, Zhipeng Fang, Byung-wook Kim, Lina Gao, Lili Ding, Eryun Zhang, Xiaoxiao Ma, Junfeng Li, Ling Li, Yang Xu, David Horne, Rongzhen Xu, Hua Yu, Ying Gu, Wendong Huang
Publicado em 2022-05-01

Raising the bar on sex and gender reporting in research

Publicado em 2022-05-01

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

Por Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant
Publicado em 2022-05-01

Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro

Por Leiping Zeng, Yanxia Liu, Xammy Huu Nguyenla, Timothy R. Abbott, Mengting Han, Yanyu Zhu, Augustine Chemparathy, Xueqiu Lin, Xinyi Chen, Haifeng Wang, Draven A. Rane, Jordan M. Spatz, Saket Jain, Arjun Rustagi, Benjamin Pinsky, Adrianna E. Zepeda, Anastasia P. Kadina, John A. Walker, Kevin Holden, Nigel Temperton, Jennifer R. Cochran, Annelise E. Barron, Michael D. Connolly, Catherine A. Blish, David B. Lewis, Sarah A. Stanley, Marie F. La Russa, Lei S. Qi
Publicado em 2022-05-01