Subtype-Specific Translocation of the δ Subtype of Protein Kinase C and Its Activation by Tyrosine Phosphorylation Induced by Ceramide in HeLa Cells

We investigated the functional roles of ceramide, an intracellular lipid mediator, in cell signaling pathways by monitoring the intracellular movement of protein kinase C (PKC) subtypes fused to green fluorescent protein (GFP) in HeLa living cells. C(2)-ceramide but not C(2)-dihydroceramide induced...

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Bibliographic Details
Main Authors: Kajimoto, Taketoshi, Ohmori, Shiho, Shirai, Yasuhito, Sakai, Norio, Saito, Naoaki
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC86731/
https://ncbi.nlm.nih.gov/pubmed/11238914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1769-1783.2001
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