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Human Osteogenesis Involves Differentiation-Dependent Increases in the Morphogenically Active 3′ Alternative Splicing Variant of Acetylcholinesterase

The extended human acetylcholinesterase (AChE) promoter contains many binding sites for osteogenic factors, including 1,25-(OH)(2) vitamin D(3) and 17β-estradiol. In differentiating osteosarcoma Saos-2 cells, both of these factors enhanced transcription of the AChE mRNA variant 3′ terminated with ex...

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Auteurs principaux: Grisaru, Dan, Lev-Lehman, Efrat, Shapira, Michael, Chaikin, Ellen, Lessing, Joseph B., Eldor, Amiram, Eckstein, Fritz, Soreq, Hermona
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC83935/
https://ncbi.nlm.nih.gov/pubmed/9858601
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