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Macrophage-derived microRNA-21 drives overwhelming glycolytic and inflammatory response during sepsis via repression of the PGE(2)/IL-10 axis.

Myeloid cells are critical for systemic inflammation, microbial control, and organ damage during sepsis. MicroRNAs are small non-coding RNAs that can dictate the outcome of sepsis. The role of myeloid-based expression of microRNA-21 (miR-21) in sepsis is inconclusive. Here we show that sepsis enhanc...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: De Melo, Paulo, Rocio Pineros Alvarez, Annie, Ye, Xiang, Blackman, Amondrea, Alves-Filho, Jose Carlos, Medeiros, Alexandra I., Rathmell, Jeffrey, Pua, Heather, Serezani, C. Henrique
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323968/
https://ncbi.nlm.nih.gov/pubmed/34301845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2001251
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