Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells

Adoptive T cell therapies for solid tumors is challenging. We generated metabolically enhanced co-activated-T cells by transducing intracellular co-stimulatory (41BB, ICOS or ICOS-27) and CD3ζ T cell receptor signaling domains followed by arming with bispecific antibodies (BiAbs) to produce armed “H...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Immunol
Egile Nagusiak: Thakur, Archana, Scholler, John, Kubicka, Ewa, Bliemeister, Edwin T., Schalk, Dana L., June, Carl H., Lum, Lawrence G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2021
Gaiak:
Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288104/
https://ncbi.nlm.nih.gov/pubmed/34290709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.690437
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