A Derivative of the D5 Monoclonal Antibody That Targets the gp41 N-Heptad Repeat of HIV-1 with Broad Tier-2-Neutralizing Activity

HIV-1 infection is initiated by the viral glycoprotein Env, which, after interaction with cellular coreceptors, adopts a transient conformation known as the prehairpin intermediate (PHI). The N-heptad repeat (NHR) is a highly conserved region of gp41 exposed in the PHI; it is the target of the FDA-a...

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Pubblicato in:J Virol
Autori principali: Rubio, Adonis A., Filsinger Interrante, Maria V., Bell, Benjamin N., Brown, Clayton L., Bruun, Theodora U. J., LaBranche, Celia C., Montefiori, David C., Kim, Peter S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274607/
https://ncbi.nlm.nih.gov/pubmed/33980592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02350-20
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