Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling

The patterning of epithelial buds is determined by the underlying signaling network. Here, we study the cross-talk between phosphoinositide 3-kinase (PI3K) and Ras signaling during lacrimal gland budding morphogenesis. Our results show that PI3K is activated by both the p85-mediated insulin-like gro...

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Vydáno v:Sci Adv
Hlavní autoři: Wang, Qian, Tao, Chenqi, Hannan, Abdul, Yoon, Sungtae, Min, Xuanyu, Peregrin, John, Qu, Xiuxia, Li, Hongge, Yu, Honglian, Zhao, Jean, Zhang, Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245041/
https://ncbi.nlm.nih.gov/pubmed/34193412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf1068
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