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Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations

The cochlea’s inaccessibility and complex nature provide significant challenges to delivering drugs and other agents uniformly, safely and efficiently, along the entire cochlear spiral. Large drug concentration gradients are formed along the cochlea when drugs are administered to the middle ear. Thi...

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Publicat a:Drug Deliv
Autors principals: Flaherty, Samuel M., Russell, Ian J., Lukashkin, Andrei N.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238068/
https://ncbi.nlm.nih.gov/pubmed/34176371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2021.1943059
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