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Probing the Substitution Pattern of Indole-Based Scaffold Reveals Potent and Selective Sphingosine Kinase 2 Inhibitors
Elevated levels of sphingosine 1-phosphate (S1P) and increased expression of sphingosine kinase isoforms (SphK1 and SphK2) have been implicated in a variety of disease states including cancer, inflammation, autoimmunity, among others. Consequently, the S1P signaling axis has become an attractive tar...
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| Publicat a: | Eur J Med Chem |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8224985/ https://ncbi.nlm.nih.gov/pubmed/33445156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.113121 |
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