SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 infection leads to lung injury remains elusive. The open reading frame 8 (ORF8) protein of SARS-CoV-2 (ORF8(SARS-CoV-2)) is a unique...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Geng, Hua, Subramanian, Saravanan, Wu, Longtao, Bu, Heng-Fu, Wang, Xiao, Du, Chao, De Plaen, Isabelle G., Tan, Xiao-Di
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221109/
https://ncbi.nlm.nih.gov/pubmed/34177923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.679482
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