[(11)C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease

OBJECTIVE: To explore the possibilities of radioligands against the mitochondrial outer membrane translocator protein (TSPO) as biomarkers for mitochondrial disease, we performed brain PET-MRI with [(11)C]PK11195 in 14 patients with genetically confirmed mitochondrial disease and 33 matched controls...

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Pubblicato in:Neurology
Autori principali: van den Ameele, Jelle, Hong, Young T., Manavaki, Roido, Kouli, Antonina, Biggs, Heather, MacIntyre, Zoe, Horvath, Rita, Yu-Wai-Man, Patrick, Reid, Evan, Williams-Gray, Caroline H., Bullmore, Ed T., Aigbirhio, Franklin I., Fryer, Tim D., Chinnery, Patrick F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205464/
https://ncbi.nlm.nih.gov/pubmed/33883237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000012033
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