Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives

BACKGROUND: Interleukin-15 (IL-15) is a critical cytokine for the development, proliferation, and function of natural killer (NK) cells, NKT cells, and CD8(+) memory T cells and has become one of the most promising protein molecules for the treatment of cancer and viral diseases. However, there are...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Microb Cell Fact
Main Authors: Xu, Huan, Shi, Mingyang, Shao, Changsheng, Li, Hao, Wu, Jing, Yu, Yin, Fang, Fang, Guo, Yugang, Xiao, Weihua
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190845/
https://ncbi.nlm.nih.gov/pubmed/34107983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01605-3
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