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DNA Methylome and Transcriptome Alterations in High Glucose-Induced Diabetic Nephropathy Cellular Model and Identification of Novel Targets for Treatment by Tanshinone IIA

Diabetic nephropathy (DN) is a diabetes complication that comes from overactivation of Renin-Angiotensin System, excessive pro-inflammatory factors, reactive oxygen species (ROS) overproduction, and potential epigenetic changes. Tanshinone IIA (TIIA), a diterpene quinone phytochemical, has been show...

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Detalles Bibliográficos
Publicado en:Chem Res Toxicol
Main Authors: Li, Wenji, Sargsyan, Davit, Wu, Renyi, Li, Shanyi, Wang, Lujing, Cheng, David, Kong, Ah-Ng
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8182679/
https://ncbi.nlm.nih.gov/pubmed/31525975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00117
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