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Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins
Spectinomycin, an aminocyclitol antibiotic, is subject to inactivation by aminoglycoside modifying enzymes (AMEs) through adenylylation or phosphorylation of the 6-hydroxy group position. In this study, the effects of deoxygenation of the 2- and 6-hydroxy group positions on the spectinomycin actinam...
Guardat en:
| Publicat a: | J Antibiot (Tokyo) |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8154590/ https://ncbi.nlm.nih.gov/pubmed/33504919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41429-021-00408-3 |
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