Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain

Cellular entry of SARS-CoV-2 requires the binding between the receptor-binding domain (RBD) of the viral Spike protein and the cellular angiotensin-converting enzyme 2 (ACE2). As such, RBD has become the major target for vaccine development, whereas RBD-specific antibodies are pursued as therapeutic...

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Vydáno v:J Virol
Hlavní autoři: Ma, Huan, Zeng, Weihong, Meng, Xiangzhi, Huang, Xiaoxue, Yang, Yunru, Zhao, Dan, Zhou, Peigen, Wang, Xiaofang, Zhao, Changcheng, Sun, Yong, Wang, Peihui, Ou, Huichao, Hu, Xiaowen, Xiang, Yan, Jin, Tengchuan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139655/
https://ncbi.nlm.nih.gov/pubmed/33658349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02438-20
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