A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia

Central leptin action rescues type 1 diabetic (T1D) hyperglycemia; however, the underlying mechanism and the identity of mediating neurons remain elusive. Here, we show that leptin receptor (LepR)-expressing neurons in arcuate (LepR(Arc)) are selectively activated in T1D. Activation of LepR(Arc) neu...

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Publicat a:Nat Commun
Autors principals: Fan, Shengjie, Xu, Yuanzhong, Lu, Yungang, Jiang, Zhiying, Li, Hongli, Morrill, Jessie C., Cai, Jing, Wu, Qi, Xu, Yong, Xue, Mingshan, Arenkiel, Benjamin R., Huang, Cheng, Tong, Qingchun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113586/
https://ncbi.nlm.nih.gov/pubmed/33976218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22940-4
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