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Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents
The design, synthesis, and biological evaluation of a series novel N1‑methyl pyrazolo[4,3-d]pyrimidines as inhibitors of tubulin polymerization and colchicine binding were described here. Synthesis of target compounds involved alkylation of the pyrazolo scaffold, which afforded two regioisomers. The...
সংরক্ষণ করুন:
| প্রকাশিত: | Bioorg Med Chem Lett |
|---|---|
| প্রধান লেখক: | , , , , , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8113149/ https://ncbi.nlm.nih.gov/pubmed/33705908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.127923 |
| ট্যাগগুলো: |
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