Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites

Regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channel by phosphoinositides is complex and controversial. In the most recent TRPV1 cryo-EM structure, endogenous phosphatidylinositol (PtdIns) was detected in the vanilloid binding site, and phosphoinos...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Yazici, Aysenur Torun, Gianti, Eleonora, Kasimova, Marina A., Lee, Bo-Hyun, Carnevale, Vincenzo, Rohacs, Tibor
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095115/
https://ncbi.nlm.nih.gov/pubmed/33766560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100573
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