GDE2-RECK Controls ADAM10 α secretase-mediated cleavage of amyloid precursor protein

A disintegrin and metalloprotease 10 (ADAM10) is the α-secretase for Amyloid precursor protein (APP). ADAM10 cleaves APP to generate neuroprotective soluble APPα (sAPPα), which precludes the generation of Aβ, a defining feature of Alzheimer’s disease (AD) pathophysiology. Reduced ADAM10 activity is...

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Bibliografiska uppgifter
I publikationen:Sci Transl Med
Huvudupphovsmän: Nakamura, Mai, Li, Yuhan, Choi, Bo-Ran, Matas-Rico, Elisa, Troncoso, Juan, Takahashi, Chiaki, Sockanathan, Shanthini
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085789/
https://ncbi.nlm.nih.gov/pubmed/33731436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abe6178
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