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GDE2-RECK Controls ADAM10 α secretase-mediated cleavage of amyloid precursor protein
A disintegrin and metalloprotease 10 (ADAM10) is the α-secretase for Amyloid precursor protein (APP). ADAM10 cleaves APP to generate neuroprotective soluble APPα (sAPPα), which precludes the generation of Aβ, a defining feature of Alzheimer’s disease (AD) pathophysiology. Reduced ADAM10 activity is...
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| Udgivet i: | Sci Transl Med |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8085789/ https://ncbi.nlm.nih.gov/pubmed/33731436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abe6178 |
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