Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico

Mutations at different stages of the mitogen-activated protein kinase (MAPK) signaling pathway lead to aberrant activation of the involved protein kinase entities. These oncogenic modifications alter signal propagation which converge on the gatekeeper kinases MEK1/2, transmitting the input signal to...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Fleischmann, Jakob, Feichtner, Andreas, DeFalco, Louis, Kugler, Valentina, Schwaighofer, Selina, Huber, Roland G, Stefan, Eduard
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Brief Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065916/
https://ncbi.nlm.nih.gov/pubmed/33808483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11040518
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