DLL3 (delta-like protein 3) expression correlates with stromal desmoplasia and lymph node metastases in medullary thyroid carcinomas

Medullary thyroid carcinomas (MTC) are rare and aggressive neuroendocrine tumors of the thyroid. About 70% of MTC are sporadic; approximately 50% of those harbor somatic RET mutation. DLL3 is widely expressed in many neuroendocrine tumors and has been evaluated as a potential therapeutic target. Sin...

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Detalhes bibliográficos
Publicado no:Endocr Connect
Main Authors: Ingenwerth, M, Brandenburg, T, Führer-Sakel, D, Goetz, M, Weber, F, Dralle, H, Schildhaus, H-U, Schmid, K W, Theurer, S
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica Ltd 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052580/
https://ncbi.nlm.nih.gov/pubmed/33617464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EC-20-0611
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