Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The viral spike (S) protein engages the human angiotensin-converting enzyme 2 (ACE2) receptor to invade host cells with ~10–15-fold higher affinity compared to SARS-CoV S-protein, making it highly infectious. Here, we...

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Gepubliceerd in:Commun Biol
Hoofdauteurs: Suryamohan, Kushal, Diwanji, Devan, Stawiski, Eric W., Gupta, Ravi, Miersch, Shane, Liu, Jiang, Chen, Chao, Jiang, Ying-Ping, Fellouse, Frederic A., Sathirapongsasuti, J. Fah, Albers, Patrick K., Deepak, Tanneeru, Saberianfar, Reza, Ratan, Aakrosh, Washburn, Gavin, Mis, Monika, Santhosh, Devi, Somasekar, Sneha, Hiranjith, G. H., Vargas, Derek, Mohan, Sangeetha, Phalke, Sameer, Kuriakose, Boney, Antony, Aju, Ustav Jr, Mart, Schuster, Stephan C., Sidhu, Sachdev, Junutula, Jagath R., Jura, Natalia, Seshagiri, Somasekar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041869/
https://ncbi.nlm.nih.gov/pubmed/33846513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02030-3
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