Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor

Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on the N-terminal tails of histones through two bromodomains (BD1 and BD2) to regulate gene transcription. Inhibiting one or both of bromodomains resulted in different phenotypes, suggesting BD1 and BD2 may have different funct...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Main Authors: Li, Jiao, Zou, Wei, Yu, Koukou, Liu, Bing, Liang, Weifeng, Wang, Lisha, Lu, Yin, Jiang, Zequn, Wang, Aiyun, Zhu, Jiapeng
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2021
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032343/
https://ncbi.nlm.nih.gov/pubmed/33820450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1906663
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