Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor

Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on the N-terminal tails of histones through two bromodomains (BD1 and BD2) to regulate gene transcription. Inhibiting one or both of bromodomains resulted in different phenotypes, suggesting BD1 and BD2 may have different funct...

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Detaylı Bibliyografya
Yayımlandı:J Enzyme Inhib Med Chem
Asıl Yazarlar: Li, Jiao, Zou, Wei, Yu, Koukou, Liu, Bing, Liang, Weifeng, Wang, Lisha, Lu, Yin, Jiang, Zequn, Wang, Aiyun, Zhu, Jiapeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2021
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032343/
https://ncbi.nlm.nih.gov/pubmed/33820450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1906663
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