Mutational and biophysical robustness in a prestabilized monobody

The fibronectin type III (FN3) monobody domain is a promising non-antibody scaffold, which features a less complex architecture than an antibody while maintaining analogous binding loops. We previously developed FN3Con, a hyperstable monobody derivative with diagnostic and therapeutic potential. Pre...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Chandler, Peter G., Tan, Li Lynn, Porebski, Benjamin T., Green, James S., Riley, Blake T., Broendum, Sebastian S., Hoke, David E., Falconer, Robert J., Munro, Trent P., Buckle, Malcolm, Jackson, Colin J., Buckle, Ashley M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010708/
https://ncbi.nlm.nih.gov/pubmed/33617878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100447
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky