The MEK1/2 Pathway as a Therapeutic Target in High-Grade Serous Ovarian Carcinoma

SIMPLE SUMMARY: High-grade serous ovarian carcinoma (HGSOC) has poor prognosis for patients due to its high rate of recurrence and acquired resistance to therapy. MEK1/2-ERK1/2 signaling pathway that controls cell proliferation and survival is active in the majority of HGSOC cases, but its functiona...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Chesnokov, Mikhail S., Khan, Imran, Park, Yeonjung, Ezell, Jessica, Mehta, Geeta, Yousif, Abdelrahman, Hong, Linda J., Buckanovich, Ronald J., Takahashi, Akimasa, Chefetz, Ilana
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8003094/
https://ncbi.nlm.nih.gov/pubmed/33803586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13061369
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