Synthesis and Structure–Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research

Epigenetic regulation is known to play a key role in progression of anti-cancer therapeutics. Lysine acetylation is an important mechanism in controlling gene expression. There has been increasing interest in bromodomain owing to its ability to modulate transcription of various genes as an epigeneti...

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Detaylı Bibliyografya
Yayımlandı:Molecules
Asıl Yazarlar: Yoo, Minjin, Park, Tae Hyun, Yoo, Miyoun, Kim, Yeongrin, Lee, Joo-Youn, Lee, Kyu Myung, Ryu, Seong Eon, Lee, Byung Il, Jung, Kwan-Young, Park, Chi Hoon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8002823/
https://ncbi.nlm.nih.gov/pubmed/33802888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26061686
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