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Potency-Enhancing Mutations of Gating Modifier Toxins for the Voltage-Gated Sodium Channel Na(V)1.7 Can Be Predicted Using Accurate Free-Energy Calculations
Gating modifier toxins (GMTs) isolated from venomous organisms such as Protoxin-II (ProTx-II) and Huwentoxin-IV (HwTx-IV) that inhibit the voltage-gated sodium channel Na(V)1.7 by binding to its voltage-sensing domain II (VSDII) have been extensively investigated as non-opioid analgesics. However, r...
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| Publicado no: | Toxins (Basel) |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8002187/ https://ncbi.nlm.nih.gov/pubmed/33800031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins13030193 |
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