HuB and HuD repress telomerase activity by dissociating HuR from TERC

The ubiquitous RNA-binding protein HuR (ELAVL1) promotes telomerase activity by associating with the telomerase noncoding RNA TERC. However, the role of the neural-specific members HuB, HuC, and HuD (ELAVL2–4) in telomerase activity is unknown. Here, we report that HuB and HuD, but not HuC, repress...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Cheng, Xiaolei, Gu, Xiaoping, Xia, Tianjiao, Ma, Zhengliang, Yang, Zhongzhou, Feng, Helen Lechen, Zhao, Yong, Ma, Wenbin, Ju, Zhenyu, Gorospe, Myriam, Yi, Xia, Tang, Hao, Wang, Wengong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
RNA and RNA-protein complexes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969021/
https://ncbi.nlm.nih.gov/pubmed/33589924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab062
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