Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins

Protein engineering has great potential for devising multifunctional recombinant proteins to serve as next-generation protein therapeutics, but it often requires drastic modifications of the parental protein scaffolds e.g., additional domains at the N/C-terminus or replacement of a domain by another...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mihara, Emiko, Watanabe, Satoshi, Bashiruddin, Nasir K., Nakamura, Nozomi, Matoba, Kyoko, Sano, Yumi, Maini, Rumit, Yin, Yizhen, Sakai, Katsuya, Arimori, Takao, Matsumoto, Kunio, Suga, Hiroaki, Takagi, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943567/
https://ncbi.nlm.nih.gov/pubmed/33750839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21875-0
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