Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2

The SARS-CoV-2 Nucleoprotein (NCAP) functions in RNA packaging during viral replication and assembly. Computational analysis of its amino acid sequence reveals a central low-complexity domain (LCD) having sequence features akin to LCDs in other proteins known to function in liquid–liquid phase separ...

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Udgivet i:bioRxiv
Main Authors: Tayeb-Fligelman, Einav, Cheng, Xinyi, Tai, Christen, Bowler, Jeannette T., Griner, Sarah, Sawaya, Michael R., Seidler, Paul M., Jiang, Yi Xiao, Lu, Jiahui, Rosenberg, Gregory M., Salwinski, Lukasz, Abskharon, Romany, Zee, Chih-Te, Hou, Ke, Li, Yan, Boyer, David R., Murray, Kevin A., Falcon, Genesis, Anderson, Daniel H., Cascio, Duilio, Saelices, Lorena, Damoiseaux, Robert, Guo, Feng, Eisenberg, David S.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941625/
https://ncbi.nlm.nih.gov/pubmed/33688654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.05.434000
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