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Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead

Acid-sensing ion channels (ASICs) are expressed in the nervous system, activated by acidosis, and implicated in pain pathways. Mambalgins are peptide inhibitors of ASIC1 and analgesic in rodents via inhibition of centrally expressed ASIC1a and peripheral ASIC1b. This activity has generated interest...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Cristofori-Armstrong, Ben, Budusan, Elena, Rash, Lachlan D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923528/
https://ncbi.nlm.nih.gov/pubmed/33602819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021581118
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