Effect of differentiation, de novo innervation, and electrical pulse stimulation on mRNA and protein expression of Na(+),K(+)-ATPase, FXYD1, and FXYD5 in cultured human skeletal muscle cells

Denervation reduces the abundance of Na(+),K(+)-ATPase (NKA) in skeletal muscle, while reinnervation increases it. Primary human skeletal muscle cells, the most widely used model to study human skeletal muscle in vitro, are usually cultured as myoblasts or myotubes without neurons and typically do n...

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Udgivet i:PLoS One
Main Authors: Jan, Vid, Miš, Katarina, Nikolic, Natasa, Dolinar, Klemen, Petrič, Metka, Bone, Andraž, Thoresen, G. Hege, Rustan, Arild C., Marš, Tomaž, Chibalin, Alexander V., Pirkmajer, Sergej
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909653/
https://ncbi.nlm.nih.gov/pubmed/33635930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0247377
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