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Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood

In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might be a common driver, across etiologies, of characteristic be...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Medendorp, William E., Bjorefeldt, Andreas, Crespo, Emmanuel L., Prakash, Mansi, Pal, Akash, Waddell, Madison L., Moore, Christopher I., Hochgeschwender, Ute
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907816/
https://ncbi.nlm.nih.gov/pubmed/33665575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102157
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