Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

BACKGROUND: Mutations in RNA polymerase (RNAP) can reduce susceptibility to ciprofloxacin in Escherichia coli, but the mechanism of transcriptional reprogramming responsible is unknown. Strains carrying ciprofloxacin-resistant (Cip(R)) rpoB mutations have reduced growth fitness and their impact on c...

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Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Brandis, Gerrit, Granström, Susanna, Leber, Anna T, Bartke, Katrin, Garoff, Linnéa, Cao, Sha, Huseby, Douglas L, Hughes, Diarmaid
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7879142/
https://ncbi.nlm.nih.gov/pubmed/33221850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa469
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