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Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response
BACKGROUND: Mutations in RNA polymerase (RNAP) can reduce susceptibility to ciprofloxacin in Escherichia coli, but the mechanism of transcriptional reprogramming responsible is unknown. Strains carrying ciprofloxacin-resistant (Cip(R)) rpoB mutations have reduced growth fitness and their impact on c...
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| Publicado no: | J Antimicrob Chemother |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7879142/ https://ncbi.nlm.nih.gov/pubmed/33221850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa469 |
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