Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation

Generation of tolerogenic peripheral regulatory T (pTreg) cells is commonly thought to involve CD103(+) gut dendritic cells (DCs), yet their role in commensal-reactive pTreg development is unclear. Using two Helicobacter-specific T cell receptor (TCR) transgenic mouse lines, we found that both CD103...

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Veröffentlicht in:eLife
Hauptverfasser: Russler-Germain, Emilie V, Yi, Jaeu, Young, Shannon, Nutsch, Katherine, Wong, Harikesh S, Ai, Teresa L, Chai, Jiani N, Durai, Vivek, Kaplan, Daniel H, Germain, Ronald N, Murphy, Kenneth M, Hsieh, Chyi-Song
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2021
Schlagworte:
Immunology and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877908/
https://ncbi.nlm.nih.gov/pubmed/33533717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54792
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