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ASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis

Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic viral encephalitis, and despite targeted antiviral therapy, outcomes remain poor. Although the innate immune system is critical for restricting herpes simplex virus type I (HSV-1) in the brain, there is evidence that prolon...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Hayes, Cooper K., Wilcox, Douglas R., Yang, Yuchen, Coleman, Grace K., Brown, Melissa A., Longnecker, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877773/
https://ncbi.nlm.nih.gov/pubmed/33524073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009285
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