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Cell-type specific knockout of peptidylglycine α-amidating monooxygenase reveals specific behavioral roles in excitatory forebrain neurons and cardiomyocytes

Neuropeptides and peptide hormones play a crucial role in integrating the many factors that affect physiologic and cognitive processes. The potency of many of these peptides requires an amidated amino acid at the C-terminus; a single enzyme, peptidylglycine α-amidating monooxygenase (PAM), catalyzes...

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Udgivet i:Genes Brain Behav
Main Authors: Powers, Kathryn G., Ma, Xin-Ming, Eipper, Betty A., Mains, Richard E.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858240/
https://ncbi.nlm.nih.gov/pubmed/32902163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gbb.12699
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