Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

Despite the effectiveness of antiretroviral (ARV) therapy, virological failure can occur in some HIV-1-infected patients in the absence of mutations in drug target genes. We previously reported that, in vitro, the lab-adapted HIV-1 NL4-3 strain can acquire resistance to the integrase inhibitor dolut...

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Foilsithe in:mBio
Main Authors: Hikichi, Yuta, Van Duyne, Rachel, Pham, Phuong, Groebner, Jennifer L., Wiegand, Ann, Mellors, John W., Kearney, Mary F., Freed, Eric O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2021
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844542/
https://ncbi.nlm.nih.gov/pubmed/33436439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03134-20
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