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The Molecular Mechanism of Chronic High-Dose Corticosterone-Induced Aggravation of Cognitive Impairment in APP/PS1 Transgenic Mice

Clinical studies have found that some Alzheimer’s disease (AD) patients suffer from Cushing’s syndrome (CS). CS is caused by the long-term release of excess glucocorticoids (GCs) from the adrenal gland, which in turn, impair brain function and induce dementia. Thus, we investigated the mechanism of...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Zhang, Shen-Qing, Cao, Long-Long, Liang, Yun-Yue, Wang, Pu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844096/
https://ncbi.nlm.nih.gov/pubmed/33519376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.613421
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