Atorvastatin Attenuates Isoflurane-Induced Activation of ROS-p38MAPK/ATF2 Pathway, Neuronal Degeneration, and Cognitive Impairment of the Aged Mice

Isoflurane, a widely used volatile anesthetic, induces neuronal apoptosis and memory impairments in various animal models. However, the potential mechanisms and effective pharmacologic agents are still not fully understood. The p38MAPK/ATF-2 pathway has been proved to regulate neuronal cell survival...

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Gepubliceerd in:Front Aging Neurosci
Hoofdauteurs: Liu, Pengfei, Gao, Quansheng, Guan, Lei, Sheng, Weixuan, Hu, Yanting, Gao, Teng, Jiang, Jingwen, Xu, Yongxing, Qiao, Hui, Xue, Xinying, Liu, Sanhong, Li, Tianzuo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840608/
https://ncbi.nlm.nih.gov/pubmed/33519423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.620946
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