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CDK1/2/5 blockade: killing two birds with one stone
Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor micro...
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| Publicado no: | Oncoimmunology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7833763/ https://ncbi.nlm.nih.gov/pubmed/33537177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2021.1875612 |
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